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Ivan Izquierdo
Dr. Ivan Antonio Izquierdo is a renowned Argentine Brazilian scientist and a pioneer in the study of the neurobiology of learning and memory. Born in 1937 in Buenos Aires, Argentina, Izquierdo has graduated in Medicine (1961) and completed his Ph.D. in Pharmacology (1962), both in the University of Buenos Aires (UBA). For nearly a decade, Izquierdo taught at National University of Cordoba (UNC), in Argentina, but, due to a number of reasons, both political (the Argentinian dictatorship) and personal (his wife, Ivone, is Brazilian), he moved to Brazil in the beginning of the 1970s, and has lived in Porto Alegre since 1978. For more than 20 years, he has worked in the "Center of Memory" of the Biochemistry Department of the Health Basic Sciences Institute (ICBS) at the Federal University of Rio Grande do Sul (UFRGS), where he has had an enormous influence on young scientists: he has trained 42 Ph.D. students, most of whom hold academic research positions in universities in Brazil and elsewhere. Recently, he moved to the Pontificial Catholic University of Rio Grande do Sul (PUCRS) where he continues with his research.
==Contributions==
Ivan Izquierdo has made several key contributions to the understanding of the cellular basis of brain processes underlying memory storage and retrieval. His research work is focused in the biological mechanisms of memory processes, employing multiple experimental approaches that range from behavioral psychobiology to neurochemistry, pharmacology, neurophysiology and experimental neurology, usually employing intracerebral microinfusions of drugs and assaying its effects upon different brain receptors, cellular processes, and, in particular, behavioral performance in different tasks. He was among the first to reveal the roles of epinephrine, dopamine, endogenous opioid peptides and acetylcholine in modulating memory consolidation and state-dependent memory retrieval. Later he has investigated benzodiazepine and GABAergic influences on memory. Some of his main achievements include the molecular bases of memory formation, retrieval, persistence and extinction in the mammal brain, the endogenous state dependency, and the functional discrimination between short and long-term memory.
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